For LAAO eligibility, what is the significance of having a CHADS2 score greater than 2?

Having a CHADS2 score greater than 2 is significant because it indicates a higher risk of thromboembolic events, particularly stroke, in patients with atrial fibrillation (AF). The CHADS2 score is widely used to assess stroke risk and is based on the presence of specific clinical risk factors: congestive heart failure, hypertension, age, diabetes mellitus, and prior stroke or transient ischemic attack. A score over 2 demonstrates an accumulation of multiple risk factors, which informs clinical decision-making regarding the necessity for anticoagulation therapy.

In this context, a higher CHADS2 score suggests that the likelihood of stroke is more pronounced, and therefore, patients are generally recommended to receive anticoagulation to reduce this risk. While there are other considerations in managing AF, the score serves as a foundational tool in determining the appropriateness of anticoagulation, particularly when considering procedural interventions like Left Atrial Appendage Occlusion. Consequently, a CHADS2 score greater than 2 correlates directly with the necessity of anticoagulation to mitigate stroke risk.