In what clinical scenario is LAAO clearly indicated?

The indication for Left Atrial Appendage Occlusion (LAAO) is clearly established in patients with atrial fibrillation who have contraindications to long-term anticoagulation. Atrial fibrillation significantly increases the risk of stroke due to the formation of thrombi in the left atrial appendage. For those patients who cannot tolerate anticoagulants due to reasons such as bleeding disorders, previous adverse reactions, or other medical considerations, LAAO serves as a viable alternative to reduce this stroke risk effectively.

By occluding the left atrial appendage, the source of thrombus formation in patients with atrial fibrillation can be eliminated, thereby providing a protective measure without the need for continuous anticoagulant therapy. This approach is crucial for managing patients whose clinical condition precludes the use of traditional anticoagulants, making LAAO a key intervention in their treatment plan.

Other scenarios, such as low blood pressure, acute myocardial infarction, or age alone, do not directly align with the primary clinical justification for LAAO regarding stroke prevention in the context of atrial fibrillation and anticoagulation contraindications.