What does the CLOSE criterion related to separation between device lobe and disc ensure?

The CLOSE criterion emphasizes the importance of maintaining a precise measured distance between the device lobe and disc during Left Atrial Appendage Occlusion procedures. This specific proximity is critical to ensure effective occlusion of the left atrial appendage while minimizing the risk of creating a space that could potentially allow for blood flow or thrombus formation. A precise distance helps to optimize device deployment, ensuring that the occlusive mechanism functions properly to prevent the embolization of blood clots that may originate from the left atrial appendage, a common concern in patients with atrial fibrillation.

If the lobe and disc were excessively far apart, it could compromise the sealing effectiveness, leading to ineffective closure. Conversely, if they were too tightly connected or fused, it could create issues related to deployment or post-procedural complications. Thus, the CLOSE criterion is designed to strike the right balance for achieving successful occlusion.