What factor influences the decision to discontinue anticoagulation therapy after LAAO?

Discontinuing anticoagulation therapy after Left Atrial Appendage Occlusion (LAAO) is primarily influenced by the individual risk factors of the patient. This consideration includes a comprehensive assessment of each patient's specific circumstances, such as their history of thromboembolism, the presence of comorbidities, and overall risk profile for stroke and bleeding.

Each patient’s unique clinical picture shapes the risk-benefit analysis regarding ongoing anticoagulation. For instance, patients with a history of stroke or transient ischemic attacks may still require anticoagulation despite undergoing LAAO due to their elevated risk of thromboembolic events. Conversely, patients with lower risk might be candidates for discontinuing anticoagulation after successful LAAO.

The other factors, while relevant to the procedure and the patient’s overall treatment plan, do not directly drive the decision to stop anticoagulation. For example, the size of the left atrial appendage can influence the effectiveness of the LAAO device but does not directly correlate with anticoagulation decisions. The procedure's location might pose logistical challenges but does not dictate anticoagulation needs after the intervention. Similarly, the patient's age can impact treatment strategies, but the decision to continue or discontinue anticoagulation