Which clinical trials are known for evaluating the effectiveness of LAAO?

The PROTECT AF and PREVAIL trials are significant studies that have been pivotal in evaluating the effectiveness of Left Atrial Appendage Occlusion (LAAO) procedures. The PROTECT AF trial was one of the first large-scale randomized controlled trials that assessed the safety and efficacy of the Watchman device for LAAO in patients with atrial fibrillation who are at risk of stroke. This trial provided critical data on the reduction of stroke risk in patients undergoing LAAO compared to traditional anticoagulation therapy.

Following PROTECT AF, the PREVAIL trial further validated the safety and effectiveness of the Watchman device, focusing on a more specific patient population and including a longer follow-up period. The PREVAIL trial demonstrated additional evidence supporting the device’s use in preventing strokes and also addressed some of the procedural complications observed in earlier trials.

Together, these trials have established a robust body of evidence that informs clinical decision-making regarding LAAO, shaping guidelines and influencing the management of patients with atrial fibrillation. Thus, these trials are cornerstone studies in the evaluation of LAAO’s effectiveness in preventing thromboembolic events.