Which patient population is most likely to benefit from LAAO procedures?

The patient population that most likely benefits from Left Atrial Appendage Occlusion (LAAO) procedures consists of individuals with non-valvular atrial fibrillation who have a high CHA2DS2-VASc score. This scoring system is used to evaluate a patient's risk of stroke based on various clinical factors such as heart failure, hypertension, age, diabetes, prior stroke, and vascular disease. Patients with non-valvular atrial fibrillation are particularly at a higher risk for thromboembolic events, especially stroke, due to the turbulence of blood flow in the left atrial appendage, which can lead to the formation of blood clots.

The primary goal of LAAO is to reduce the risk of stroke by closing off the left atrial appendage, thereby preventing blood clots that might otherwise travel to the brain. Those with a high CHA2DS2-VASc score are considered to have a significant stroke risk and are ideal candidates for this intervention, especially if they are unable to tolerate anticoagulation therapy.

Other patient populations, such as those with valvular heart disease, coronary artery disease, or heart failure, may have overlapping risks but do not specifically benefit from LAAO in the same targeted way